Open AccessGenetic control of susceptibility to collagen‐induced arthritis in T cell receptor β‐chain transgenic mice
Author(s) -
Mori Lucia,
de Libero Gennaro
Publication year - 1998
Publication title -
arthritis & rheumatism
Language(s) - English
Resource type - Journals
eISSN - 1529-0131
pISSN - 0004-3591
DOI - 10.1002/1529-0131(199802)41:2<256::aid-art9>3.0.co;2-e
Subject(s) - transgene , genetically modified mouse , arthritis , receptor , immunology , biology , microbiology and biotechnology , chemistry , genetics , gene
Objective To study the genes in the mouse background which predispose to the development of collagen‐induced arthritis (CIA). Methods T cell receptor β transgenic (TCRβL) mice that have a T cell repertoire that predisposes to the development of CIA were used. Classic genetic studies and microsatellite gene mapping were done in (SWR‐βL × DBA/1)F 2 hybrid mice. Results Besides TCRβ, major histocompatibility complex class II, and IgH‐C, at least 2 other genes are absolutely required for CIA development in these mice. A strict association of CIA with the presence of functional complement C5 allele ( Hc 1 ) was found, suggesting that Hc 1 or a closely linked gene might be one of these essential genes. Conclusion This study provides new evidence of the pathogenetic role of complement C5 in CIA. Furthermore, these transgenic mice may facilitate molecular identification of other genes that predispose to CIA.