Open AccessClinical studies of antibodies binding polyriboadenylic acid in systemic lupus erythematosus
Author(s) -
Pillarisetty Rao J.,
Talal Norman
Publication year - 1976
Publication title -
arthritis & rheumatism
Language(s) - English
Resource type - Journals
eISSN - 1529-0131
pISSN - 0004-3591
DOI - 10.1002/1529-0131(197607/08)19:4<705::aid-art1780190408>3.0.co;2-k
Subject(s) - antibody , pathogenesis , rheumatoid arthritis , radioimmunoassay , immunology , lupus erythematosus , medicine , endocrinology
Antibodies to polyriboadenylic acid (poly rA) are demonstrated by filter radioimmunoassay in 75% of patients with systemic lupus erythematosus (SLE), in 54% of patients with discoid lupus erythematosus, and in only 0–7% of normal controls and patients with rheumatoid arthritis or Sjögren's syndrome. These antibodies are distinct from antibodies to single‐ and double‐stranded DNA and double‐stranded RNA. Poly rA binding is associated with IgM and IgG serum fractions. Because poly rA may have a role in the transcription of mRNA in mammalian cells and viruses, antibodies to poly rA may be important clues to virologic and immunogenetic mechanisms in the pathogenesis of SLE.