Open AccessPrednisone and azathioprine compared to prednisone plus low‐dose azathioprine and cyclophosphamide in the treatment of diffuse lupus nephritis
Author(s) -
Ginzler Ellen,
Diamond Herbert,
Guttadauria Maria,
Kaplan David
Publication year - 1976
Publication title -
arthritis & rheumatism
Language(s) - English
Resource type - Journals
eISSN - 1529-0131
pISSN - 0004-3591
DOI - 10.1002/1529-0131(197607/08)19:4<693::aid-art1780190406>3.0.co;2-2
Subject(s) - azathioprine , prednisone , cyclophosphamide , medicine , lupus nephritis , gastroenterology , dermatology , chemotherapy , disease
A 1‐year double‐blind crossover study comparing prednisone and azathioprine to prednisone plus low‐dose azathioprine and cyclophosphamide was carried out in 14 patients with diffuse lupus nephritis. Low‐dose triple therapy had no apparent therapeutic advantage over prednisone plus azathioprine. Cyclophosphamide‐induced ovarian failure and hematuria were not avoided by its use in low dose.