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Zebrafish nma is involved in TGFβ family signaling
Author(s) -
Tsang Michael,
Kim Richard,
de Caestecker Mark P.,
Kudoh Tetsuhiro,
Roberts Anita B.,
Dawid Igor B.
Publication year - 2000
Publication title -
genesis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.093
H-Index - 110
eISSN - 1526-968X
pISSN - 1526-954X
DOI - 10.1002/1526-968x(200010)28:2<47::aid-gene20>3.0.co;2-s
Subject(s) - zebrafish , xenopus , bmpr2 , microbiology and biotechnology , biology , bone morphogenetic protein , bone morphogenetic protein 10 , signal transduction , smad2 protein , receptor , gene , transforming growth factor beta , genetics , bone morphogenetic protein 7
Abstract Summary: Bone morphogenetic proteins (BMP) are members of the TGFβ superfamily of secreted factors with important regulatory functions during embryogenesis. We have isolated the zebrafish gene, nma , that encodes a protein with high sequence similarity to human NMA and Xenopus Bambi. It is also similar to TGFβ type I serine/theronine kinase receptors in the extracellular ligand‐binding domain but lacks a cytoplasmic kinase domain. During development, nma expression is similar to that of bmp2b and bmp4 , and analysis in the dorsalized and ventralized zebrafish mutants swirl and chordino indicates that nma is regulated by BMP signaling. Overexpression of nma during zebrafish and Xenopus development resulted in phenotypes that appear to be based on inhibition of BMP signaling. Biochemically, NMA can associate with TGFβ type II receptors and bind to TGFβ ligand. We propose that nma is a BMP‐regulated gene whose function is to attenuate BMP signaling during development through interactions with type II receptors and ligands. genesis 28:47–57, 2000. Published 2000 Wiley‐Liss, Inc.