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Mouse paraxial protocadherin is expressed in trunk mesoderm and is not essential for mouse development
Author(s) -
Yamamoto Akihito,
Kemp Caroline,
Bachiller Daniel,
Geissert Douglas,
De Robertis E.M.
Publication year - 2000
Publication title -
genesis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.093
H-Index - 110
eISSN - 1526-968X
pISSN - 1526-954X
DOI - 10.1002/1526-968x(200006)27:2<49::aid-gene10>3.0.co;2-7
Subject(s) - gastrulation , paraxial mesoderm , biology , primitive streak , somite , hindbrain , microbiology and biotechnology , anatomy , blastoderm , zebrafish , notochord , protocadherin , mesoderm , xenopus , epiboly , embryo , embryogenesis , genetics , cadherin , cell , gene , embryonic stem cell
Summary: Paraxial protocadherin (PAPC) is a cell adhesion molecule that marks cells undergoing convergence‐extension cell movements in Xenopus and zebrafish gastrulating embryos. Here a mouse homologue ( mpapc ) was identified and characterized. During early‐ to mid‐gastrulation, mpapc is expressed in the primitive streak as the trunk mesoderm undergoes morphogenetic cell movements. At head‐fold stage mpapc expression becomes localized to paraxial regions in which somites are formed in the segmental plate. At later stages, mpapc displays a complex expression pattern in cerebral cortex, olfactory bulb, inferior colliculus, and in longitudinal stripes in hindbrain. To analyze the effect of the loss of PAPC function during mouse development, a null allele of the mouse papc gene was generated. Homozygous animals show no defects in their skeleton and are viable and fertile. genesis 27:49–57, 2000. © 2000 Wiley‐Liss, Inc.