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The chemical and biological properties of methoxyfenozide, a new insecticidal ecdysteroid agonist
Author(s) -
Carlson Glenn R,
Dhadialla Tarlochan S,
Hunter Ricky,
Jansson Richard K,
Jany Christine S,
Lidert Zev,
Slawecki Richard A
Publication year - 2001
Publication title -
pest management science
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.296
H-Index - 125
eISSN - 1526-4998
pISSN - 1526-498X
DOI - 10.1002/1526-4998(200102)57:2<115::aid-ps245>3.0.co;2-a
Subject(s) - ecdysteroid , agonist , noctuidae , lepidoptera genitalia , 20 hydroxyecdysone , biology , pyralidae , ecdysone , tortricidae , botany , toxicology , receptor , larva , biochemistry
Methoxyfenozide [ N‐tert ‐butyl‐ N ′‐(3‐methoxy‐ o ‐toluoyl)‐3,5‐xylohydrazide; RH‐2485] is the newest diacylhydrazine insecticide to reach the marketplace. It binds with very high affinity to the ecdysone receptor complex (EcR:USP) in lepidopteran insects [ K d = 0.5 n M ( Plodia )], where it functions as a potent agonist, or mimic, of the insect molting hormone, 20‐hydroxyecdysone (20E). Methoxyfenozide exhibits high insecticidal efficacy against a wide range of important caterpillar pests, including many members of the family Pyralidae, Pieridae, Tortricidae and Noctuidae. It is most effective when ingested by the target caterpillar, but it also has some topical and ovicidal properties. It is modestly root systemic, but not significantly leaf‐systemic. Evidence collected to date indicates that methoxyfenozide has an excellent margin of safety to non‐target organisms, including a wide range of non‐target and beneficial insects. © 2001 Society of Chemical Industry