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Predicting the activity of the natural phytotoxic diphenyl ether cyperine using Comparative Molecular Field Analysis
Author(s) -
Dayan Franck E,
Allen Stacy N
Publication year - 2000
Publication title -
pest management science
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.296
H-Index - 125
eISSN - 1526-4998
pISSN - 1526-498X
DOI - 10.1002/1526-4998(200008)56:8<717::aid-ps183>3.0.co;2-o
Subject(s) - protoporphyrinogen oxidase , diphenyl ether , chemistry , ether , stereochemistry , enantiomer , active site , molecular model , enzyme , biochemistry , organic chemistry
Protoporphyrinogen oxidase (Protox) is the target site of a large number of commercial herbicides. Previous QSARs performed at a two‐dimensional level reproduced the activity of individual data sets relatively well, but these models could not be used to predict the activity of structurally related derivatives. We have developed a more reliable model by applying three‐dimensional molecular techniques to a set of 31 phenyl ether analogues. Inhibitory activity at the molecular site of action was chosen because it circumvents the effects of uptake, translocation and metabolism of the compounds occurring in whole‐plant studies. Increased predictability was achieved by aligning the diphenyl ether analogues along the trifluoromethyl phenyl ( q 2 = 0.70) ring rather than along the nitrophenyl ( q 2 = 0.65) ring or along the centroids ( q 2 = 0.69). This new analysis differentiated between R and S enantiomers and allowed the prediction of the inhibitory activity of the natural diphenyl ether cyperine. The prediction model suggests that the binding of cyperine on the active site of Protox is stereospecific. Published in 2000 for SCI by John Wiley & Sons, Ltd.