Premium
Increase of separation resolution through field enhancement in microchips
Author(s) -
Kerby Matthew B.,
Chien RingLing
Publication year - 2002
Publication title -
electrophoresis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.666
H-Index - 158
eISSN - 1522-2683
pISSN - 0173-0835
DOI - 10.1002/1522-2683(200210)23:20<3545::aid-elps3545>3.0.co;2-j
Subject(s) - resolution (logic) , microfluidics , chip , materials science , electrophoresis , electrode , voltage , optoelectronics , dynamic range , nanotechnology , separation (statistics) , analytical chemistry (journal) , chromatography , computer science , chemistry , electronic engineering , electrical engineering , engineering , telecommunications , artificial intelligence , machine learning
An enhanced ability to separate charged species from neutral compounds in a microfluidic chip is demonstrated using a chip design with low‐resistance electrode channels operating with a multiport pressure/voltage controller. A factor of 2.7 improvement in resolution was obtained from chips made using identical mask designs but different etch depth protocols. Greater separation power allows one to cover a wider dynamic range for compounds with different electrophoretic mobilities.