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Application of self‐assembly techniques in the design of biocompatible protein microarray surfaces
Author(s) -
Schaeferling Michael,
Schiller Stefan,
Paul Hubert,
Kruschina Margit,
Pavlickova Petra,
Meerkamp Mark,
Giammasi Chiara,
Kambhampati Dev
Publication year - 2002
Publication title -
electrophoresis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.666
H-Index - 158
eISSN - 1522-2683
pISSN - 0173-0835
DOI - 10.1002/1522-2683(200209)23:18<3097::aid-elps3097>3.0.co;2-g
Subject(s) - biocompatible material , biocompatibility , nanotechnology , protein microarray , materials science , spotting , chemistry , microarray , computer science , biomedical engineering , engineering , biochemistry , gene expression , metallurgy , gene , artificial intelligence
This review focuses on the application of novel technologies for generating biocompatible surfaces for high‐throughput screening (HTS) of proteins. Various methods of coupling and spotting proteins on self‐assembled monolayer (SAM) surfaces will be described along with the protein chip challenges pertaining to spot homogeneity, morphology, biocompatibility and reproducibility.