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Enantioseparation of glutethimide and its 5‐OH‐metabolite in capillary electrophoresis and study of selector‐selectand interactions using one‐dimensional rotating frame nuclear Overhauser and exchange spectroscopy
Author(s) -
Chankvetadze Bezhan,
Burjanadze Naira,
Bergander Klaus,
Blaschke Gottfried
Publication year - 2002
Publication title -
electrophoresis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.666
H-Index - 158
eISSN - 1522-2683
pISSN - 0173-0835
DOI - 10.1002/1522-2683(200206)23:12<1906::aid-elps1906>3.0.co;2-#
Subject(s) - chemistry , nuclear overhauser effect , capillary electrophoresis , metabolite , enantiomer , spectroscopy , cyclodextrin , nuclear magnetic resonance spectroscopy , chromatography , analytical chemistry (journal) , nuclear magnetic resonance , stereochemistry , biochemistry , physics , quantum mechanics
Enantioseparation of glutethimide (GT) and its 5‐hydroxy metabolite (5‐OH‐GT) has been studied with several charged cyclodextrin (CD) derivatives. The emphasis was made on the enantiomer migration order of GT and simultaneous enantioseparation of GT and 5‐OH‐GT. The possible structural differences of GT complexes with three different single isomer charged CD derivatives were studied using one‐dimensional rotating frame nuclear Overhauser and exchange spectroscopy (1‐D ROESY).