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Theory of sequence effects on DNA translocation through proteins and nanopores
Author(s) -
Muthukumar Murugappan
Publication year - 2002
Publication title -
electrophoresis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.666
H-Index - 158
eISSN - 1522-2683
pISSN - 0173-0835
DOI - 10.1002/1522-2683(200205)23:10<1417::aid-elps1417>3.0.co;2-o
Subject(s) - nanopore , sequence (biology) , chromosomal translocation , dna , polymer , monomer , biophysics , chemistry , computational biology , biological system , biology , nanotechnology , genetics , materials science , gene , organic chemistry
A general formula for the sequence effects on the average translocation time of a polymer passing through a narrow hole under a chemical potential gradient is provided. The utility of the general expression is illustrated by considering the diblock sequence of a polymer with two kinds of monomers. The experimental conditions required for sufficient discrimination of various sequences are addressed.