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Nonaqueous capillary electrophoretic separation of basic enantiomers using octakis(2,3‐ O ‐dimethyl‐6‐ O ‐sulfo)‐γ‐cyclodextrin, a new, single‐isomer chiral resolving agent
Author(s) -
Busby M. Brent,
Maldonado Omar,
Vigh Gyula
Publication year - 2002
Publication title -
electrophoresis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.666
H-Index - 158
eISSN - 1522-2683
pISSN - 0173-0835
DOI - 10.1002/1522-2683(200202)23:3<456::aid-elps456>3.0.co;2-x
Subject(s) - enantiomer , chemistry , capillary electrophoresis , cyclodextrin , methanol , electrolyte , analyte , electrophoresis , ionic strength , chromatography , base (topology) , resolution (logic) , analytical chemistry (journal) , organic chemistry , aqueous solution , mathematical analysis , mathematics , electrode , artificial intelligence , computer science
The enantiomers of 34 pharmaceutical weak‐base analytes were separated by nonaqueous capillary electrophoresis in acidic methanol background electrolytes using the sodium salt of the new, single‐isomer chiral resolving agent, octakis(2,3‐ O ‐dimethyl‐6‐ O ‐sulfo)‐γ‐cyclodextrin (ODMS). The effective mobilities, separation selectivities and peak resolution values of the weak‐base analytes were determined as a function of the ODMS concentration in the 0–40 m M range and were found to follow the theoretical predictions of the charged resolving agent migration model (CHARM model) modified for ionic strength effects. Fast, efficient separations were achieved for both comparatively small and large enantiomers.