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Application of sweeping to micellar electrokinetic chromatography‐atmospheric pressure chemical ionization‐mass spectrometric analysis of environmental pollutants
Author(s) -
Isoo Kentaro,
Otsuka Koji,
Terabe Shigeru
Publication year - 2001
Publication title -
electrophoresis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.666
H-Index - 158
eISSN - 1522-2683
pISSN - 0173-0835
DOI - 10.1002/1522-2683(200109)22:16<3426::aid-elps3426>3.0.co;2-i
Subject(s) - atmospheric pressure chemical ionization , chemistry , micellar electrokinetic chromatography , chromatography , mass spectrometry , analytical chemistry (journal) , chemical ionization , environmental chemistry , ionization , detection limit , organic chemistry , ion
An application study of sweeping, an on‐line sample concentration technique, to micellar electrokinetic chromatography (MEKC) directly combined with mass spectrometry (MS) using an atmospheric pressure chemical ionization (APCI) interface, namely MEKC‐APCI‐MS, was investigated to enhance the concentration sensitivity for the analysis of environmental pollutants. Under a neutral condition, around 100‐fold increase in the concentration sensitivity was achieved for several aromatic amines and alkyl phthalates as test samples by sweeping‐MEKC‐APCI‐MS compared to conventional MEKC‐APCI‐MS, whereas under an acidic condition, 100 to 600‐fold sensitivity enhancement was gained for similar solutes. Linearity of the corrected peak area obtained in the mass chromatogram against the sample concentration was examined for 3,4‐dichloroaniline and diisopropyl phthalate (DIPP). The estimated limits of detection for 3,4‐dichloroaniline and DIPP were 0.6 and 0.4 ppm, respectively, in terms of the injected sample concentration.