Premium
Chiral separation of pharmacologically active dihydropyrimidinones with carboxymethyl‐ β‐cyclodextrin
Author(s) -
Lecnik Oliver,
Schmid Martin G.,
Kappe C. Oliver,
Gübitz Gerald
Publication year - 2001
Publication title -
electrophoresis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.666
H-Index - 158
eISSN - 1522-2683
pISSN - 0173-0835
DOI - 10.1002/1522-2683(200109)22:15<3198::aid-elps3198>3.0.co;2-b
Subject(s) - capillary electrophoresis , chemistry , cyclodextrin , chromatography , methanol , optically active , chromatographic separation , high performance liquid chromatography , organic chemistry
We report on the chiral separation of pharmacologically active dihydropyrimidinones by capillary electrophoresis (CE) using carboxymethyl‐β‐cyclodextrin as chiral selector. The influence of selector concentration, pH, and the addition of varying amounts of methanol is investigated. Out of 21 compounds investigated, 19 were resolved, 13 with baseline separation.*