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A New Stereoselective Synthesis of Acitretin (= Soriatane ® , Neotigason ® )
Author(s) -
Andriamialisoa Zo,
Valla Alain,
Cartier Dominique,
Labia Roger
Publication year - 2002
Publication title -
helvetica chimica acta
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.74
H-Index - 82
eISSN - 1522-2675
pISSN - 0018-019X
DOI - 10.1002/1522-2675(200209)85:9<2926::aid-hlca2926>3.0.co;2-5
Subject(s) - chemistry , stereoselectivity , aldehyde , key (lock) , stereochemistry , combinatorial chemistry , organic chemistry , catalysis , ecology , biology
A new synthesis of acitretin via a C 15 +C 5 route is reported. The C 15 unit is the key step, involving a procedure that provides the required (all‐ E )‐C 15 ‐aldehyde with high stereoselectivity.