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New Rotenoids from Roots of Mirabilis jalapa
Author(s) -
YiFen Wang,
JiJun Chen,
Yan Yang,
YongTang Zheng,
ShaoZong Tang,
ShiDe Luo
Publication year - 2002
Publication title -
helvetica chimica acta
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.74
H-Index - 82
eISSN - 1522-2675
pISSN - 0018-019X
DOI - 10.1002/1522-2675(200208)85:8<2342::aid-hlca2342>3.0.co;2-s
Subject(s) - chemistry , dept , stereochemistry , two dimensional nuclear magnetic resonance spectroscopy , carbon 13 nmr , diol , traditional medicine , organic chemistry , medicine
Four new rotenoids named mirabijalone A–D ( 1 – 4 ), together with 9‐ O ‐methyl‐4‐hydroxyboeravinone B ( 5 ), boeravinone C ( 6 ) and F ( 7 ), and 1,2,3,4‐tetrahydro‐1‐methylisoquinoline‐7,8‐diol ( 8 ), were isolated from the roots of Mirabilis jalapa. The structures of these compounds were determined on the basis of their HR‐EI‐MS, IR, UV, 1 H‐ and 13 C‐NMR (DEPT), and 2D NMR (HMQC, HMBC, NOESY) data. Among them, 1,2,3,4‐tetrahydro‐1‐methylisoquinoline‐7,8‐diol ( 8 ) showed a 48% inhibition against HIV‐1 reverse transcriptase at 210 μg/ml. For systematic names, see Exper. Part.