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Determination of the Absolute Configuration of (−)‐Mirtazapine by Vibrational Circular Dichroism
Author(s) -
Freedman Teresa B.,
Dukor Rina K.,
van Hoof Peter J. C. M.,
Kellenbach Edwin R.,
Nafie Laurence A.
Publication year - 2002
Publication title -
helvetica chimica acta
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.74
H-Index - 82
eISSN - 1522-2675
pISSN - 0018-019X
DOI - 10.1002/1522-2675(200204)85:4<1160::aid-hlca1160>3.0.co;2-t
Subject(s) - absolute configuration , vibrational circular dichroism , chemistry , mirtazapine , circular dichroism , enantiomer , stereochemistry , neuroscience , biology , hippocampus , antidepressant
The absolute configuration of the (−)‐enantiomer of mirtazapine was determined by means of vibrational circular dichroism (VCD). The observed VCD of (−)‐mirtazapine showed excellent correlation with the calculated VCD of the ( R )‐enantiomer. This is in agreement with the absolute configuration as determined by independent synthesis starting from ( R )‐phenylglycine.