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Perfluoro‐Tagged Benzyloxycarbonyl Protecting Group and Its Application in Fluorous Biphasic Systems
Author(s) -
Schwinn Dominik,
Bannwarth Willi
Publication year - 2002
Publication title -
helvetica chimica acta
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.74
H-Index - 82
eISSN - 1522-2675
pISSN - 0018-019X
DOI - 10.1002/1522-2675(200201)85:1<255::aid-hlca255>3.0.co;2-5
Subject(s) - chemistry , hydrogenolysis , protecting group , extraction (chemistry) , group (periodic table) , combinatorial chemistry , chromatography , organic chemistry , catalysis , alkyl
The synthesis of a new perfluoro‐tagged benzyloxycarbonyl protecting group is reported, as well as its application in the parallel protection of amines. Isolation of the protected amines was performed by simple liquid‐liquid extraction between perfluorinated and organic solvents. Deprotection was achieved by standard hydrogenolysis. The novel protecting group was also applied to cyclization protocols leading to quinazoline‐2,4‐diones. These products were isolated by simple extraction procedures