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The Reaction of Amines with Benzyl Halides under CO 2 Atmosphere
Author(s) -
Shi Min,
Shen YuMei
Publication year - 2001
Publication title -
helvetica chimica acta
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.74
H-Index - 82
eISSN - 1522-2675
pISSN - 0018-019X
DOI - 10.1002/1522-2675(20011114)84:11<3357::aid-hlca3357>3.0.co;2-p
Subject(s) - chemistry , halide , toluene , atmosphere (unit) , solvent , primary (astronomy) , organic chemistry , polarity (international relations) , amine gas treating , base (topology) , hexane , mathematical analysis , biochemistry , mathematics , astronomy , cell , physics , thermodynamics
To find a useful, practical, and ecologically safer way to synthesize protected amines, the reactions of amines with benzyl halides under CO 2 atmosphere were systematically examined. For primary amines, the CO 2 ‐inserted products were obtained in higher yields in the presence of DBU as a base, under a high pressure of CO 2 , and in a low‐polarity solvent (toluene/hexane 1 : 1). Secondary amines gave only low yields of CO 2 ‐inserted products.