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Novel Basic Isoflavones as Inhibitors of Bone Resorption
Author(s) -
Delcanale Maurizio,
Amari Gabriele,
Armani Elisabetta,
Lipreri Milco,
Civelli Maurizio,
Galbiati Elisabetta,
Giossi Massimo,
Caruso Paola Lorenza,
Crivori Patrizia,
Carrupt PierreAlain,
Testa Bernard
Publication year - 2001
Publication title -
helvetica chimica acta
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.74
H-Index - 82
eISSN - 1522-2675
pISSN - 0018-019X
DOI - 10.1002/1522-2675(20010815)84:8<2417::aid-hlca2417>3.0.co;2-n
Subject(s) - chemistry , isoflavones , bone resorption , resorption , ring (chemistry) , side chain , parathyroid hormone , stereochemistry , hormone , biochemistry , endocrinology , calcium , organic chemistry , medicine , polymer
A number of aminoalkoxy analogues of ipriflavone (=7‐(1‐methylethoxy)isoflavone) were prepared and examined for their capacity to inhibit bone resorption induced by bovine parathyroid hormone fragment 1 – 34. Good‐to‐high activities were found for 7‐(aminoalkoxy)isoflavone analogues. Their activity was influenced by a number of structural features, among which the length of the basic side chain, the basicity of the amino group, and the nature and position of substituents on the 3‐phenyl ring. 4′‐(Aminoalkoxy)ipriflavone derivatives were less active.