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A New Convenient Liquid‐ and Solid‐Phase Synthesis of Quinoxalines from ( E )‐3‐Diazenylbut‐2‐enes
Author(s) -
Attanasi Orazio A.,
De Crescentini Lucia,
Filippone Paolino,
Mantellini Fabio,
Santeusanio Stefania
Publication year - 2001
Publication title -
helvetica chimica acta
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.74
H-Index - 82
eISSN - 1522-2675
pISSN - 0018-019X
DOI - 10.1002/1522-2675(20010815)84:8<2379::aid-hlca2379>3.0.co;2-5
Subject(s) - chemistry , phase (matter) , solid phase synthesis , combinatorial chemistry , organic chemistry , peptide , biochemistry
3‐{[( tert ‐Butoxy)carbonyl]diazenyl}but‐2‐enoates react in tetrahydrofuran at room temperature with aromatic 1,2‐diamines to give 3‐methylquinoxaline‐2‐carboxylates. These products were also obtained in solid‐phase synthesis, by using polymer‐bound 3‐diazenylbut‐2‐enes.