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Synthesis and Protein Binding of (4‐Carboxybutyl)carbamoyl‐ Substituted Taxoids
Author(s) -
Blitzke Torsten,
Baranovsky Alexander,
Schneider Bernd
Publication year - 2001
Publication title -
helvetica chimica acta
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.74
H-Index - 82
eISSN - 1522-2675
pISSN - 0018-019X
DOI - 10.1002/1522-2675(20010711)84:7<1989::aid-hlca1989>3.0.co;2-m
Subject(s) - chemistry , paclitaxel , trimethylsilyl , bovine serum albumin , conjugated system , mass spectrometry , stereochemistry , combinatorial chemistry , organic chemistry , chromatography , chemotherapy , medicine , polymer
(4‐Carboxybutyl)carbamates 5 and 6 , as well as 10 , derived from 10‐ O ‐deacetylbaccatin III ( 1 ) and paclitaxel ( 2 ), respectively, were synthesized by reaction of unprotected 1 and 2′‐ O ‐(methoxyacetyl)paclitaxel ( 8 ), respectively, with trimethylsilyl 5‐isocyanatopentanoate in good yields. The carbamoyl‐taxoids were conjugated to bovine‐serum albumin and analyzed by MALDI‐TOF mass spectrometry.