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Pentopyranosyl Oligonucleotide Systems, Communication No. 10 , The α ‐ L ‐Lyxopyranosyl‐(4′→2′)‐oligonucleotide System
Author(s) -
Reck Folkert,
Wippo Harald,
Kudick René,
Krishnamurthy Ramanarayanan,
Eschenmoser Albert
Publication year - 2001
Publication title -
helvetica chimica acta
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.74
H-Index - 82
eISSN - 1522-2675
pISSN - 0018-019X
DOI - 10.1002/1522-2675(20010613)84:6<1778::aid-hlca1778>3.0.co;2-3
Subject(s) - oligonucleotide , chemistry , rna , nucleic acid , base pair , ribose , stereochemistry , computational biology , dna , biochemistry , gene , biology , enzyme
To determine whether the remarkable chemical properties of the pyranosyl isomer of RNA as an informational Watson‐Crick base‐pairing system are unique to the pentopyranosyl‐(4′→2′)‐oligonucleotide isomer derived from the RNA‐building block D ‐ribose, studies on the entire family of diastereoisomeric pyranosyl‐(4′→2′)‐oligonucleotide systems deriving from D ‐ribose, L ‐lyxose, D ‐xylose, and L ‐arabinose were carried out. The result of these extended studies is unambiguous: not only pyranosyl‐RNA, but all members of the pentopyranosyl‐(4′→2′)‐oligonucleotide family are highly efficient Watson‐Crick base‐pairing systems. Their synthesis and pairing properties will be described in a series of publications in this journal. The present paper describes the α ‐ L ‐lyxopyranosyl‐(4′→2′)‐system.