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Synthesis of a New, Highly Fluorescent Amino Acid Derivative: N ‐[( tert ‐Butoxy)carbonyl]‐3‐[2‐(1 H ‐indol‐3‐yl)benzoxazol‐5‐yl]‐ L ‐alanine Methyl Ester
Author(s) -
Guzow Katarzyna,
Szabelski Mariusz,
Malicka Joanna,
Wiczk Wiesław
Publication year - 2001
Publication title -
helvetica chimica acta
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.74
H-Index - 82
eISSN - 1522-2675
pISSN - 0018-019X
DOI - 10.1002/1522-2675(20010516)84:5<1086::aid-hlca1086>3.0.co;2-d
Subject(s) - chemistry , fluorescence , derivative (finance) , alanine , yield (engineering) , tyrosine , indole test , amino acid , stereochemistry , biochemistry , physics , quantum mechanics , financial economics , economics , materials science , metallurgy
A simple method of synthesis of a new, highly fluorescent amino acid derivative from the simple and generally available substrates 3‐nitro‐ L ‐tyrosine and 1 H ‐indole‐3‐carbaldehyde is described. The obtained compound, N ‐[( tert ‐butoxy)carbonyl]‐3‐[2‐(1 H ‐indol‐3‐yl)benzoxazol‐5‐yl]‐ L ‐alanine methyl ester ( 4 ), possesses a high fluorescence quantum yield. The described method illustrates a new possibility of synthesis of amino acid derivatives possessing desirable photophysical properties.