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New Insights into the Degradation of Qinghaosu (Artemisinin) Mediated by Non‐Heme‐Iron Chelates, and Their Relevance to the Antimalarial Mechanism
Author(s) -
Wu Yikang,
Yue ZhengYu,
Liu HeHua
Publication year - 2001
Publication title -
helvetica chimica acta
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.74
H-Index - 82
eISSN - 1522-2675
pISSN - 0018-019X
DOI - 10.1002/1522-2675(20010418)84:4<928::aid-hlca928>3.0.co;2-i
Subject(s) - chemistry , artemisinin , chelation , heme , degradation (telecommunications) , combinatorial chemistry , cleavage (geology) , cysteine , mechanism (biology) , stereochemistry , biochemistry , organic chemistry , plasmodium falciparum , enzyme , malaria , telecommunications , philosophy , geotechnical engineering , epistemology , fracture (geology) , computer science , engineering , immunology , biology
Probing the degradation of qinghaosu ( 1 ) induced by cysteine‐iron chelates by varying the acidity of the reaction medium led to interesting insights into the cleavage of 1 , which help to elucidate the antimalarial action of the 1,2,4‐trioxanes.