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Chingazumianine, a Novel Dichlorinated Alkaloid from Corydalis koidzumiana
Author(s) -
Chan ShengChing,
Chung MeiIng,
Yen MingHong,
Lien GuanHuei,
Lin ChunNan,
Chiang Michael Y.
Publication year - 2000
Publication title -
helvetica chimica acta
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.74
H-Index - 82
eISSN - 1522-2675
pISSN - 0018-019X
DOI - 10.1002/1522-2675(20001108)83:11<2993::aid-hlca2993>3.0.co;2-a
Subject(s) - chemistry , protopine , alkaloid , coptisine , palmatine , tetrahydropalmatine , stereochemistry , corydalis , medicine , alternative medicine , traditional chinese medicine , pathology
A dichlorinated alkaloid with a novel skeleton, chingazumianine ( 1 ), was isolated from the herb Corydalis koidzumiana , and its structure elucidated by spectroscopic data and X‐ray crystallographic analysis. In citrate‐treated human platelet‐rich plasma (PRP), known compounds, i.e. , protopine ( 2 ), (±)‐tetrahydropalmatine ( 3 ), and palmatine ( 4 ), isolated from this plant, showed significant inhibition of secondary aggregation induced by adrenaline in a concentration‐dependent manner, suggesting that the antiplatelet effects of these compounds is mainly due to an inhibitory effect on thromboxane formation.