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Helicterins A – F, Six New Dimeric (7.5′,8.2′)‐Neolignans from the Indonesian Medicinal Plant Helicteres isora
Author(s) -
Tezuka Yasuhiro,
Terazono Masataka,
Kusumoto Tomoco I.,
Hatanaka Yasumaru,
Kadota Shigetoshi,
Hattori Masao,
Namba Tsuneo,
Kikuchi Tohru,
Tanaka Ken,
Supriyatna Sutardjo
Publication year - 2000
Publication title -
helvetica chimica acta
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.74
H-Index - 82
eISSN - 1522-2675
pISSN - 0018-019X
DOI - 10.1002/1522-2675(20001108)83:11<2908::aid-hlca2908>3.0.co;2-z
Subject(s) - chemistry , sterculiaceae , octene , traditional medicine , indonesian , stereochemistry , botany , biochemistry , biology , medicine , ethylene , catalysis , linguistics , philosophy
During a chemical study of Indonesian medicinal plants, we examined the constituents of fruits of Helicteres isora L. (Sterculiaceae), one of the famous Jamu medicines. From a H 2 O extract of the fruits, we isolated six new neolignans, the helicterins A – F ( 1 – 6 ), and elucidated their structures by spectral analyses. Helicterins A – F ( 1 – 6 ) are dimeric (7.5′,8.2′)‐neolignans with a bicyclo[2.2.2]octene C‐framework, and showed mild inhibitory activity against reverse transcriptase from avian myeloblastosis virus.