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A Comparison of RNA with DNA in Template‐Directed Synthesis
Author(s) -
Zielinski Magdalene,
Kozlov Igor A.,
Orgel Leslie E.
Publication year - 2000
Publication title -
helvetica chimica acta
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.74
H-Index - 82
eISSN - 1522-2675
pISSN - 0018-019X
DOI - 10.1002/1522-2675(20000809)83:8<1678::aid-hlca1678>3.0.co;2-p
Subject(s) - chemistry , template , rna , copying , dna , nucleoside , combinatorial chemistry , computational biology , stereochemistry , biochemistry , nanotechnology , genetics , biology , gene , materials science
Nonenzymatic template‐directed copying of RNA sequences rich in cytidylic acid using nucleoside 5′‐(2‐methylimidazol‐1‐yl phosphates) as substrates is substantially more efficient than the copying of corresponding DNA sequences. However, many sequences cannot be copied, and the prospect of replication in this system is remote, even for RNA. Surprisingly, wobble‐pairing leads to much more efficient incorporation of G opposite U on RNA templates than of G opposite T on DNA templates.