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Perfusion‐weighted imaging of interictal hypoperfusion in temporal lobe epilepsy using FAIR‐HASTE: Comparison with H 2 15 O PET measurements
Author(s) -
Liu HoLing,
Kochunov Peter,
Hou Jinwen,
Pu Yonglin,
Mahankali Srikanth,
Feng ChingMei,
Yee SeongHwan,
Wan YungLiang,
Fox Peter T.,
Gao JiaHong
Publication year - 2001
Publication title -
magnetic resonance in medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.696
H-Index - 225
eISSN - 1522-2594
pISSN - 0740-3194
DOI - 10.1002/1522-2594(200103)45:3<431::aid-mrm1056>3.0.co;2-e
Subject(s) - ictal , perfusion , cerebral blood flow , temporal lobe , epilepsy , magnetic resonance imaging , nuclear medicine , perfusion scanning , arterial spin labeling , medicine , radiology , psychiatry
To detect perfusion abnormalities in areas of high magnetic susceptibility in the brain, an arterial spin‐labeling MRI technique utilizing flow‐sensitive alternating inversion recovery (FAIR) and half‐Fourier single shot turbo spin‐echo (HASTE) for spin preparation and image acquisition, respectively, was developed. It was initially tested in a functional study involving visual stimulation, and was able to detect significant activation with an increase (approximately 70%) in relative cerebral blood flow. Subsequently, it was applied in a clinical situation in eight patients with temporal lobe epilepsy (TLE). The perfusion‐weighted images obtained showed no susceptibility artifacts even in the region of the inferior temporal lobe and were able to detect interictal hypoperfusion in TLE. The results were compared with those derived from H 2 15 O PET perfusion imaging in each patient. A statistically significant correlation (r = 0.75, P < 0.05) was found between results acquired from these two modalities. Magn Reson Med 45:431–435, 2001. © 2001 Wiley‐Liss, Inc.