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Functional MRI of human auditory cortex using block and event‐related designs
Author(s) -
Le Tuong Huu,
Patel Sandy,
Roberts Timothy P.L.
Publication year - 2001
Publication title -
magnetic resonance in medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.696
H-Index - 225
eISSN - 1522-2594
pISSN - 0740-3194
DOI - 10.1002/1522-2594(200102)45:2<254::aid-mrm1034>3.0.co;2-j
Subject(s) - tonotopy , auditory cortex , stimulus (psychology) , block design , functional magnetic resonance imaging , block (permutation group theory) , neuroscience , audiology , psychology , medicine , mathematics , cognitive psychology , geometry , combinatorics
fMRI of human auditory cortex response to sinusoidal tones of 200, 1000, and 3000 Hz was evaluated using block design and conventional and “silent” event‐related designs. Conventional event‐related fMRI revealed the timecourse of the BOLD response (∼5 sec to peak, ∼4 sec full‐width‐half‐max, and ∼14 sec recovery to baseline). Both event‐related, but not block, designs provided evidence for tonotopic organization in auditory cortex. Sources of low‐frequency activation were more lateral and anterior than the sources of high‐frequency activation ( P ≤ 0.05). In the block designs, repeated rapid stimulus presentation and the co‐incidence of scanner noise preclude definition of tonotopic organization revealed in event‐related approaches. Magn Reson Med 45:254–260, 2001. © 2001 Wiley‐Liss, Inc.