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Quantitative 31 P spectroscopic imaging of human brain at 4 Tesla: Assessment of gray and white matter differences of phosphocreatine and ATP
Author(s) -
Hetherington H.P.,
Spencer D.D.,
Vaughan J.T.,
Pan J.W.
Publication year - 2001
Publication title -
magnetic resonance in medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.696
H-Index - 225
eISSN - 1522-2594
pISSN - 0740-3194
DOI - 10.1002/1522-2594(200101)45:1<46::aid-mrm1008>3.0.co;2-n
Subject(s) - phosphocreatine , white matter , cerebellum , human brain , brain tissue , metabolite , chemistry , nuclear magnetic resonance , magnetic resonance imaging , medicine , nuclear medicine , neuroscience , biology , energy metabolism , physics , radiology
This report describes the implementation and application of a multicompartment analysis of 31 P spectroscopic imaging data to determine the tissue‐specific heterogeneities in metabolite content in the human brain and surrounding tissue. Using this information and a multicompartment regression analysis the phosphocreatine and ATP content of “pure” cerebral gray and white matter, the cerebellum, and skeletal muscle was determined in a group of 10 healthy volunteers. The data were converted to mM units using previously reported values for the T 1 s of phosphocreatine and ATP at 4 T, the water content of human brain, and an external reference for absolute quantification. The phosphocreatine concentration in cerebral gray and white matter, the cerebellum, and skeletal muscle was 3.53 ± 0.33, 3.33 ± 0.37, 3.75 ± 0.66, and 25.8 ± 2.3 mM, respectively. The ATP concentration in cerebral gray and white matter, the cerebellum, and skeletal muscle was 2.19 ± 0.33, 3.41 ± 0.33, 1.75 ± 0.58, and 8.5 ± 1.9 mM, respectively. Magn Reson Med 45:46–52, 2001. © 2001 Wiley‐Liss, Inc.