Premium
Quantifying tracer levels of 2 H 2 O enrichment from microliter amounts of plasma and urine by 2 H NMR
Author(s) -
Jones John G.,
Merritt Matthew,
Malloy Craig
Publication year - 2001
Publication title -
magnetic resonance in medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.696
H-Index - 225
eISSN - 1522-2594
pISSN - 0740-3194
DOI - 10.1002/1522-2594(200101)45:1<156::aid-mrm1020>3.0.co;2-z
Subject(s) - tracer , chemistry , urine , chromatography , biochemistry , physics , nuclear physics
A simple and sensitive 2 H NMR measurement of 2 H 2 O enrichment from a 10 μl volume of body fluid is presented. The method allows 2 H‐enrichment levels of 0.1% or above to be rapidly determined from 10 μl of plasma or urine. The measurement is insensitive to the presence of plasma protein, allowing direct analysis of 2 H 2 O enrichment from native plasma samples. Magn Reson Med 45:156–158, 2001. © 2001 Wiley‐Liss, Inc.