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Noninvasive assessment of cardiac ischemic injury using 87 Rb and 23 Na MR imaging, 31 P MR, and optical spectroscopy
Author(s) -
Kupriyanov V.V.,
Dai G.,
Shaw R.A.,
Sun J.,
Jilkina O.,
Luo Z.,
Mantsch H.,
Deslauriers R.
Publication year - 2000
Publication title -
magnetic resonance in medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.696
H-Index - 225
eISSN - 1522-2594
pISSN - 0740-3194
DOI - 10.1002/1522-2594(200012)44:6<899::aid-mrm11>3.0.co;2-7
Subject(s) - ischemia , anterior wall , occlusion , chemistry , magnetic resonance imaging , ischemic injury , nuclear medicine , nuclear magnetic resonance , medicine , cardiology , radiology , physics
The aim of the study was to compare and analyze different noninvasive indices of cell damage in the isolated pig heart model of regional ischemia. We used 23 Na and 87 Rb MR imaging to evaluate Na + /K + balance, 31 P MR spectroscopy to measure energetics, and optical spectroscopy to assess oxymyoglobin (MbO 2 ). Hearts were subjected to 120‐min occlusion of the left anterior descending artery and were then reperfused for 120 min. Reperfusion resulted in an increase in 23 Na (37 ± 18% of the posterior wall) and decrease in 87 Rb (55 ± 15%) image intensities, partial recovery of PCr, ATP, the total phosphates, and MbO 2 in the anterior wall. The above changes are consistent with the irreversible cell damage in the anterior wall, confirmed by lack of staining with triphenyltetrazolium chloride. Changes in Na + and Rb + in the infarct area inversely correlated and their ratio is a more sensitive index of cell injury than either of them alone. Magn Reson Med 44:899–908, 2000. Published 2000 Wiley‐Liss, Inc.