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In vivo quantitative microimaging of rat spinal cord at 7T
Author(s) -
Franconi F.,
Lemaire L.,
Marescaux L.,
Jallet P.,
Le Jeune J.J.
Publication year - 2000
Publication title -
magnetic resonance in medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.696
H-Index - 225
eISSN - 1522-2594
pISSN - 0740-3194
DOI - 10.1002/1522-2594(200012)44:6<893::aid-mrm10>3.0.co;2-g
Subject(s) - spinal cord , in vivo , nuclear magnetic resonance , cord , chemistry , nuclear medicine , anatomy , medicine , physics , biology , surgery , microbiology and biotechnology , psychiatry
In vivo T 2 , ADC, and MT properties of the GM and WM of the rat spinal cord were measured at 7T in the cervical region. The GM T 2 , T 2GM = 43.2 ± 1.0 msec is significantly reduced compared to the WM T 2 , T 2WM = 57.0 ± 1.6 msec. Diffusion is anisotropic for both GM and WM, with a larger ADC value along the cord axis (ADC GM// = 1.05 ± 0.09 10 −9 m 2 sec −1 and ADC WM// = 1.85 ± 0.18 10 −9 m 2 sec −1 ) than perpendicular to this plane (ADC GM ⊥ ∼ 0.50 * 10 −9 m 2 sec −1 and ADC WM ⊥ ∼ 0.18 * 10 −9 m 2 sec −1 ). The MT properties do not significantly differ between the WM and the GM, but allow one to distinguish the thin CSF layer from the WM. DWI with the sensitizing gradient perpendicular to the cord axis leads to the best contrast between GM and WM in the cervical region. Magn Reson Med 44:893–898, 2000. © 2000 Wiley‐Liss, Inc.