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Macromolecule and water magnetization exchange modeling in articular cartilage
Author(s) -
Lattanzio PierreJean,
Marshall K. Wayne,
Damyanovich Andrei Z.,
Peemoeller Hartwig
Publication year - 2000
Publication title -
magnetic resonance in medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.696
H-Index - 225
eISSN - 1522-2594
pISSN - 0740-3194
DOI - 10.1002/1522-2594(200012)44:6<840::aid-mrm4>3.0.co;2-k
Subject(s) - proteoglycan , magnetization transfer , magnetization , cartilage , chemistry , relaxation (psychology) , macromolecule , biophysics , osteoarthritis , coupling (piping) , nuclear magnetic resonance , articular cartilage , extracellular matrix , anatomy , materials science , biochemistry , pathology , composite material , magnetic resonance imaging , physics , biology , medicine , magnetic field , alternative medicine , quantum mechanics , radiology
Magnetization exchange effects between the matrix macromolecules (e.g., collagen and proteoglycan) and water were examined in normal, deuterated, and proteoglycan‐depleted articular cartilage. Relaxation results ( T 2 , T 1ρ , and T 1 ) suggested that a four‐site exchange scheme provided an accurate model for articular cartilage relaxation and interspin group coupling details. Magnetization exchange within the collagen–bulk‐water, proteoglycan‐collagen, and collagen fibrillar water‐collagen cartilage subsystems were quantified. Although collagen–bulk‐water was the largest of the cartilage coupling subsystems (∼90% signal) and is exploited in MRI, the rates of magnetization transfer (MT) within the latter subsystems were appreciably larger. Magnetization exchange rates for proteoglycan‐collagen and collagen fibrillar water‐collagen were 120 s −1 and 4.4 s −1 , respectively. The observation of these latter two exchange subsystems suggested potential clinical MRI‐MT applications in detecting molecular abnormalities associated with osteoarthritis. Magn Reson Med 44:840–851, 2000. © 2000 Wiley‐Liss, Inc.