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Gd‐DTPA relaxivity depends on macromolecular content
Author(s) -
Stanisz Greg J.,
Henkelman R. Mark
Publication year - 2000
Publication title -
magnetic resonance in medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.696
H-Index - 225
eISSN - 1522-2594
pISSN - 0740-3194
DOI - 10.1002/1522-2594(200011)44:5<665::aid-mrm1>3.0.co;2-m
Subject(s) - macromolecule , chemistry , gadolinium , macromolecular substances , nuclear magnetic resonance , biochemistry , physics , organic chemistry
Gd‐DTPA T 1 relaxivity of water protons was measured at 1.5 T and room temperature as a function of macromolecular content in model systems. Gd‐DTPA relaxivity was found to increase with macromolecular concentration. The results of this study indicate that the Gd‐DTPA relaxivity in tissue extracellular compartment could be as much as 30–70% higher than that of Gd‐DTPA in saline. Quantitative MR analyses that use T 1 as an estimation of local Gd‐DTPA concentration require a priori determination of the Gd relaxivity in tissue. Magn Reson Med 44:665–667, 2000. © 2000 Wiley‐Liss, Inc.