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Semiselective POCE NMR spectroscopy
Author(s) -
Henry PierreGilles,
Roussel Ronan,
Vaufrey Françoise,
Dautry Caroline,
Bloch Gilles
Publication year - 2000
Publication title -
magnetic resonance in medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.696
H-Index - 225
eISSN - 1522-2594
pISSN - 0740-3194
DOI - 10.1002/1522-2594(200009)44:3<395::aid-mrm9>3.0.co;2-5
Subject(s) - coherence (philosophical gambling strategy) , nuclear magnetic resonance , quantum , spectroscopy , sensitivity (control systems) , nuclear magnetic resonance spectroscopy , zero (linguistics) , glutamate receptor , spectral line , chemistry , physics , computer science , quantum mechanics , linguistics , philosophy , receptor , biochemistry , electronic engineering , engineering
A new scheme is proposed to edit separately glutamate C 3 and C 4 resonances of 1 H bound to 13 C, in order to resolve these two signals which overlap at intermediate magnetic fields (1.5 T‐3 T), commonly available for human brain studies. The two edited spectra are obtained by combining the individual acquisitions from a four‐scan measurement in two different ways. The four acquisitions correspond to the two steps of the classical POCE scheme combined with another two‐scan module, where the relative phases of the C 3 and C 4 1 H resonances are manipulated using zero quantum and double quantum coherence pathways. This new technique exhibits the same sensitivity as POCE and allows the 13 C labeling of C 3 and C 4 glutamate from [1‐ 13 C]glucose to be monitored separately in the rat brain at 3 T. Magn Reson Med 44:395–400, 2000. © 2000 Wiley‐Liss, Inc.