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Comparison of the quantification precision of human short echo time 1 H spectroscopy at 1.5 and 4.0 Tesla
Author(s) -
Bartha R.,
Drost D.J.,
Me R.S.,
Williamson P.C.
Publication year - 2000
Publication title -
magnetic resonance in medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.696
H-Index - 225
eISSN - 1522-2594
pISSN - 0740-3194
DOI - 10.1002/1522-2594(200008)44:2<185::aid-mrm4>3.0.co;2-v
Subject(s) - nuclear magnetic resonance , echo (communications protocol) , chemistry , computer science , physics , computer network
Precise quantification of human in vivo short echo time 1 H spectra remains problematic at clinical field strengths due to broad peak linewidths and low signal‐to‐noise ratio (SNR). In this study, multiple STEAM spectra (TE = 20 ms, volume = 8 cm 3 ) were acquired in a single individual at 1.5 T and 4 T to compare quantification precision. Test–retest STEAM spectra (volume = 1.5 cm 3 ) were also acquired from the anterior cingulate and thalamus of 10 individuals at 4.0 T. Metabolite levels were quantified using automated software that incorporated field strength‐specific prior knowledge. With the distinct methods of data acquisition, processing, and fitting used in this study, peak height SNR increased ∼80% while peak linewidth increased by ∼50% in the 8 cm 3 volumes at 4.0 T compared to 1.5 T, resulting in an average increase in quantification precision of 39%. Metabolite levels from test–retest data (1.5 cm 3 voxels at 4.0 T) were quantified with similar inter‐ and intraindividual variability. Magn Reson Med 44:185–192, 2000. Published 2000 Wiley‐Liss, Inc.