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Measurements of human brain ethanol T 2 by spectroscopic imaging at 4 T
Author(s) -
Sammi Manoj K.,
Pan Jullie W.,
Telang Frank W.,
Schuhlein Donna,
Molina Patricia E.,
Volkow Nora D.,
Springer Charles S.,
Hetherington Hoby P.
Publication year - 2000
Publication title -
magnetic resonance in medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.696
H-Index - 225
eISSN - 1522-2594
pISSN - 0740-3194
DOI - 10.1002/1522-2594(200007)44:1<35::aid-mrm7>3.0.co;2-g
Subject(s) - ethanol , chemistry , white matter , nuclear magnetic resonance , human brain , creatine , magnetic resonance imaging , physics , biochemistry , medicine , psychiatry , radiology
Previous MRS measurements of ethanol in human brain have yielded a range of transverse relaxation times for ethanol methyl resonance at 1.5 T (200–380 ms). To determine the T 2 of the methyl proton resonance of ethanol in human brain, 8 × 8 spectroscopic images were acquired at 16 different TE values. A frequency‐selective refocusing pulse was used to suppress J‐modulation of the ethanol triplet, permitting nonintegral multiples of 1/J to be used for TE values. The measured T 2 values for the methyl resonances of ethanol, creatine, and N‐acetyl aspartate in mixed tissues were 82 ± 12, 148 ± 20, and 227 ± 25 ms, respectively. Regression analysis of the measured T 2 as a function of gray matter content indicates a shorter T 2 value for ethanol in pure white matter compared to that in pure gray matter. Magn Reson Med 44:35–40, 2000. © 2000 Wiley‐Liss, Inc.