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Temporal changes of cerebral metabolites and striatal lesions in acute 3‐nitropropionic acid intoxication in the rat
Author(s) -
Lee WangTso,
Lee ChangShin,
Pan YongLi,
Chang Chen
Publication year - 2000
Publication title -
magnetic resonance in medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.696
H-Index - 225
eISSN - 1522-2594
pISSN - 0740-3194
DOI - 10.1002/1522-2594(200007)44:1<29::aid-mrm6>3.0.co;2-8
Subject(s) - in vivo , chemistry , metabolite , neurodegeneration , medicine , biochemistry , pharmacology , anesthesia , biology , disease , microbiology and biotechnology
To investigate the mechanisms of neuronal death in neurodegeneration, in vivo localized proton magnetic resonance spectroscopy ( 1 H‐MRS) and diffusion‐weighted MRI (DWI) were used to evaluate temporal changes in rat striata after administration of 3‐nitropropionic acid. It was found that N‐acetylaspartate (NAA) reduction, with nearly simultaneous evidence of striatal lesions in DWI, was preceded by a significant and progressive increase of acetate. Shortly before the NAA levels decreased to the lowest point, acetate levels peaked and began to gradually decline toward the control levels. These results suggest that acetate increase may arise from fatty acid degradation, inhibition of succinate dehydrogenase and possible NAA hydrolysis. The elevated acetate may provide a source of acetyl group for membrane repair during excitotoxic brain injury. Magn Reson Med 44:29–34, 2000. © 2000 Wiley‐Liss, Inc.