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Fast echo planar based correlation‐peak imaging: Demonstration on the rat brain in vivo
Author(s) -
Mayer Dirk,
Dreher Wolfgang,
Leibfritz Dieter
Publication year - 2000
Publication title -
magnetic resonance in medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.696
H-Index - 225
eISSN - 1522-2594
pISSN - 0740-3194
DOI - 10.1002/1522-2594(200007)44:1<23::aid-mrm5>3.0.co;2-t
Subject(s) - nuclear magnetic resonance , imaging phantom , in vivo , planar , excitation , chemistry , resolution (logic) , echo time , nuclear magnetic resonance spectroscopy , physics , materials science , magnetic resonance imaging , optics , computer science , biology , medicine , computer graphics (images) , microbiology and biotechnology , radiology , quantum mechanics , artificial intelligence
Two‐dimensional correlation spectroscopy (2D‐COSY) was combined with a fast echo planar based spectroscopic imaging technique in a new sequence. It can be optimized according to the coupling patterns of particular metabolites by using a constant time (CT) variant of COSY with chemical shift selective excitation and refocusing. Experiments were performed with an evolution time of 110 ms which was determined by simulating the CT‐COSY experiment at several evolution times for the spin systems of myo ‐inositol (Ins) and taurine (Tau). The sequence has a minimum total measurement time of 17 min and was tested on a spherical phantom filled with a solution of Ins. The in vivo application of this method on the healthy rat brain demonstrates its improved spectral resolution as cross‐peak signals from both Ins and Tau can be separated clearly. Magn Reson Med 44:23–28, 2000. © 2000 Wiley‐Liss, Inc.