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Comparison of simultaneously measured perfusion and BOLD signal increases during brain activation with T 1 ‐based tissue identification
Author(s) -
Luh WenMing,
Wong Eric C.,
Bandettini Peter A.,
Ward B. Douglas,
Hyde James S.
Publication year - 2000
Publication title -
magnetic resonance in medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.696
H-Index - 225
eISSN - 1522-2594
pISSN - 0740-3194
DOI - 10.1002/1522-2594(200007)44:1<137::aid-mrm20>3.0.co;2-r
Subject(s) - voxel , perfusion , signal (programming language) , parenchyma , perfusion scanning , nuclear magnetic resonance , biomedical engineering , nuclear medicine , chemistry , medicine , physics , computer science , pathology , cardiology , radiology , programming language
Perfusion and blood oxygenation level‐dependent (BOLD) signals were simultaneously measured during a finger‐tapping task at 3T using QUIPSS II with thin‐slice TI 1 periodic saturation, a modified pulsed arterial spin labeling technique that provides quantitative measurement of perfusion. Perfusion and BOLD signal changes due to motor activation were obtained and correlated with the T 1 values estimated from echo‐planar imaging (EPI)‐based T 1 maps on a voxel‐by‐voxel basis. The peak perfusion signal occurs in voxels with a T 1 of brain parenchyma while the peak BOLD signal occurs in voxels with a T 1 characteristic of blood and cerebrospinal fluid. The locations of the peak signals of functional BOLD and perfusion only partially overlap on the order of 40%. Perfusion activation maps will likely represent the sites of neuronal activity better than do BOLD activation maps. Magn Reson Med 44:137–143, 2000. © 2000 Wiley‐Liss, Inc.