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A protocol for assessing subtraction errors of arterial spin‐tagging perfusion techniques in human brain
Author(s) -
Yongbi Martin N.,
Tan Charlene X.,
Frank Joseph A.,
Duyn Jeff H.
Publication year - 2000
Publication title -
magnetic resonance in medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.696
H-Index - 225
eISSN - 1522-2594
pISSN - 0740-3194
DOI - 10.1002/1522-2594(200006)43:6<896::aid-mrm17>3.0.co;2-j
Subject(s) - subtraction , arterial spin labeling , imaging phantom , perfusion , multislice , nuclear medicine , perfusion scanning , computer science , medicine , nuclear magnetic resonance , biomedical engineering , radiology , physics , mathematics , arithmetic
A protocol for assessing signal contributions from static tissue (subtraction errors) in perfusion images acquired with arterial spin‐labeling (ASL) techniques in human brain is proposed. The method exploits the reduction of blood T 1 caused by the clinically available paramagnetic contrast agent, gadopentetate dimeglumine (Gd‐DTPA). The protocol is demonstrated clinically with multislice FAIR images acquired before, during, and after Gd‐DTPA administration using a range of selective inversion widths. Perfusion images acquired postcontrast for selective inversion widths large enough (threshold) to avoid interaction with the imaging slice had signal intensities reduced to noise level, as opposed to subtraction errors manifested on images acquired using inversion widths below the threshold. The need for these experiments to be performed in vivo is further illustrated by comparison with phantom results. The protocol allows a one‐time calibration of relevant ASL parameters (e.g., selective inversion widths) in vivo, which may otherwise cause subtraction errors. Magn Reson Med 43:896–900, 2000. Published 2000 Wiley‐Liss, Inc.