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In vivo gallbladder bile diffusion coefficient measurement by diffusion‐weighted echo planar imaging in hamster fed normal and lithogenic diets
Author(s) -
Tiffon Bernard,
Parquet Michel,
Dubrac Sandrine,
Lutton Claude,
Volk Andreas
Publication year - 2000
Publication title -
magnetic resonance in medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.696
H-Index - 225
eISSN - 1522-2594
pISSN - 0740-3194
DOI - 10.1002/1522-2594(200006)43:6<854::aid-mrm11>3.0.co;2-e
Subject(s) - gallbladder , in vivo , hamster , effective diffusion coefficient , diffusion , viscosity , chemistry , nuclear magnetic resonance , cholesterol , bile acid , coefficient of variation , nuclear medicine , materials science , medicine , biology , magnetic resonance imaging , chromatography , radiology , biochemistry , physics , microbiology and biotechnology , composite material , thermodynamics
It is shown that in vivo measurement of bile water apparent diffusion coefficient (ADC) by diffusion‐weighted echo‐planar imaging (EPI) in hamster gallbladder is possible providing motion artifact‐free ADC values. These ADC values are used to estimate bile viscosity variation induced by normal diets, cholesterol gallstone‐inducing diets, and an antilithiasic drug, and to determine if a link exists between bile viscosity and cholesterol gallstone formation. Measurements were performed at 4.7 T with respiratory triggering in five groups of hamsters fed a commercial (RC) or a semisynthetic (SSD) diet, a SSD containing 0.2% hyodeoxycholic acid (SSD+HDC) and two lithogenic diets (LD5, LD10). ADC decreased significantly in LD10 (2.15 ± 0.07 × 10 −3 mm 2 s −1 ) and SSD+HDC (2.03 ± 0.04) compared to RC (2.40 ± 0.05) but not in the most lithogenic LD5 diet (2.33 ± 0.06). No direct relationship was found between bile viscosity and gallstone incidence; however, viscosity seems to be related to lipid contents of diets. Magn Reson Med 43:854–859, 2000. © 2000 Wiley‐Liss, Inc.