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Utility of simultaneously acquired gradient‐echo and spin‐echo cerebral blood volume and morphology maps in brain tumor patients
Author(s) -
Donahue Kathleen M.,
Krouwer Hendrikus G.J.,
Rand Scott D.,
Pathak Arvind P.,
Marszalkowski Cathy S.,
Censky Steven C.,
Prost Robert W.
Publication year - 2000
Publication title -
magnetic resonance in medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.696
H-Index - 225
eISSN - 1522-2594
pISSN - 0740-3194
DOI - 10.1002/1522-2594(200006)43:6<845::aid-mrm10>3.0.co;2-j
Subject(s) - echo (communications protocol) , gradient echo , spin echo , nuclear magnetic resonance , volume (thermodynamics) , morphology (biology) , cerebral blood volume , magnetic resonance imaging , brain size , brain tumor , medicine , physics , radiology , computer science , pathology , biology , computer network , genetics , quantum mechanics
An interleaved gradient‐echo (GE) / spin‐echo (SE) EPI sequence was used to acquire images during the first pass of a susceptibility contrast agent, in patients with brain tumors. Maps of 1) GE (total) rCBV (relative cerebral blood volume), 2) SE (microvascular) rCBV, both corrected for T 1 leakage effects, and 3) (Δ R 2 */Δ R 2 ), a potential marker of averaged vessel diameter, were determined. Both GE rCBV and Δ R 2 */Δ R 2 correlated strongly with tumor grade ( P = 0.01, P = 0.01, n = 15), while SE rCBV did not ( P = 0.24, n = 15). When the GE rCBV data were not corrected for leakage effects, the correlation with tumor grade was no longer significant ( P = 0.09, n = 15). These findings suggest that MRI measurements of total blood volume fraction (corrected for agent extravasation) and Δ R 2 */Δ R 2 , as opposed to maps of microvascular volume, may prove to be the most appropriate markers for the evaluation of tumor angiogenesis (the induction of new blood vessels) and antiangiogenic therapies. Magn Reson Med 43:845–853, 2000. © 2000 Wiley‐Liss, Inc.