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Simultaneous quantitative cerebral perfusion and Gd‐DTPA extravasation measurement with dual‐echo dynamic susceptibility contrast MRI
Author(s) -
Vonken Evertjan Ph.A.,
van Osch Matthias J.P.,
Bakker Chris J.G.,
Viergever Max A.
Publication year - 2000
Publication title -
magnetic resonance in medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.696
H-Index - 225
eISSN - 1522-2594
pISSN - 0740-3194
DOI - 10.1002/1522-2594(200006)43:6<820::aid-mrm7>3.0.co;2-f
Subject(s) - extravasation , perfusion , cerebral blood volume , dynamic contrast enhanced mri , blood volume , cerebral perfusion pressure , perfusion scanning , medicine , nuclear medicine , magnetic resonance imaging , radiology , pathology , cardiology
Quantification of cerebral perfusion using dynamic susceptibility contrast MRI generally relies on the assumption of an intact blood–brain barrier. The present study proposes a method to correct the tissue response function that does not require this assumption, thus, allowing perfusion studies in, for example, high‐grade brain tumors. The correction for contrast extravasation in the tissue during the bolus passage is based on a two‐compartment kinetic model. The method separates the intravascular hemodynamic response and the extravascular component and returns the corrected tissue response function for perfusion quantification as well as the extravasation rate constant of the vasculature. Results of simulation experiments with different degrees of contrast extravasation are presented. The clinical potential is illustrated by determination of the perfusion and extravasation of a glioblastoma multiforme. The correction scheme proves to be fast and reliable even in cases of low signal‐to‐noise ratio. It is applicable whether extravasation occurs or not. When extravasation is present, application of the proposed method is mandatory for accurate cerebral blood volume measurements. Magn Reson Med 43:820–827, 2000. © 2000 Wiley‐Liss, Inc.