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Simultaneous MRI measurement of blood flow, blood volume, and capillary permeability in mammary tumors using two different contrast agents
Author(s) -
Henderson Elizabeth,
Sykes Jane,
Drost Dick,
Weinmann HannsJoachim,
Rutt Brian K.,
Lee TingYim
Publication year - 2000
Publication title -
journal of magnetic resonance imaging
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.563
H-Index - 160
eISSN - 1522-2586
pISSN - 1053-1807
DOI - 10.1002/1522-2586(200012)12:6<991::aid-jmri26>3.0.co;2-1
Subject(s) - magnetic resonance imaging , blood flow , vascular permeability , capillary action , permeability (electromagnetism) , gadolinium , nuclear magnetic resonance , nuclear medicine , gadolinium dtpa , contrast (vision) , blood volume , dynamic contrast , chemistry , biomedical engineering , materials science , pathology , medicine , radiology , physics , biochemistry , organic chemistry , membrane , composite material , optics
A technique for the simultaneous measurement of three vascular parameters: blood flow (Fρ), blood volume (v b ), and the capillary permeability‐surface area product (PSρ) in breast tumors using dynamic contrast‐enhanced magnetic resonance imaging (MRI) is presented. Features of the technique include measurement of precontrast tumor T 1 , rapid temporal sampling, measurement of the arterial input function, and use of a distributed parameter tracer kinetic model. Parameter measurements are compared that were determined using two contrast agents of different molecular weights, gadolinium‐diethylene triamine pentaacetic acid (Gd‐DTPA; 0.6 kDa) and Gadomer‐17 (17 kDa), in 18 spontaneous canine mammary tumors. Measurements of Fρ and v b corresponded well with literature values, and the mean PSρ measured using Gd‐DTPA was a factor of 15 higher than that measured using Gadomer‐17. J. Magn. Reson. Imaging 2000;12:991–1003. © 2000 Wiley‐Liss, Inc.