Premium
Evaluation of nonperfused myocardial ischemia with MRI and an intravascular USPIO contrast agent in an ex vivo pig model
Author(s) -
Bjerner Tomas,
Ericsson Anders,
Wikström Gerhard,
Johansson Lars,
Nilsson Stefan,
Ahlström Håkan,
Hemmingsson Anders
Publication year - 2000
Publication title -
journal of magnetic resonance imaging
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.563
H-Index - 160
eISSN - 1522-2586
pISSN - 1053-1807
DOI - 10.1002/1522-2586(200012)12:6<866::aid-jmri9>3.0.co;2-q
Subject(s) - ex vivo , magnetic resonance imaging , medicine , in vivo , ligation , ischemia , nuclear medicine , cardiology , radiology , microbiology and biotechnology , biology
The ultrasmall superparamagnetic iron oxide (USPIO) preparation NC100150 Injection (Clariscan; Nycomed Imaging, Oslo, Norway) was tested for its ability to delineate nonperfused myocardium under steady‐state conditions. An experimental animal model of focal myocardial ischemia induced by ligation of the distal part of the left anterior descending artery was used. The contrast agent was administered in four doses: 0, 4, 8, and 12 mg Fe/kg body weight. Magnetic resonance examination ex vivo, including T1‐, T2‐, and T2*‐weighted sequences, was performed. Nonperfused myocardium was determined by fluorescein. The best delineation of nonperfused myocardium was found with a T1‐weighted inversion recovery/turbo spin‐echo sequence and doses of 4 and 8 mg Fe/kg body weight, where 95% of the volume was discernible at the dose of 4 mg Fe/kg body weight. The results suggest that steady‐state imaging by T1‐weighted sequence with the use of NC100150 Injection to delineate nonperfused myocardium is feasible. J. Magn. Reson. Imaging 2000;12:866–872. © 2000 Wiley‐Liss, Inc.