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Changes in baseline cerebral blood flow in humans do not influence regional cerebral blood flow response to photic stimulation
Author(s) -
Li TieQiang,
Kastrup Andreas,
Moseley Michael E.,
Glover Gary H.
Publication year - 2000
Publication title -
journal of magnetic resonance imaging
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.563
H-Index - 160
eISSN - 1522-2586
pISSN - 1053-1807
DOI - 10.1002/1522-2586(200011)12:5<757::aid-jmri14>3.0.co;2-4
Subject(s) - cerebral blood flow , hypercapnia , stimulation , medicine , photic stimulation , anesthesia , blood flow , functional magnetic resonance imaging , cerebral cortex , hemodynamics , cardiology , psychology , neuroscience , respiratory system , visual perception , perception
The effect of changes in baseline regional cerebral blood flow (rCBF) values on the cerebral blood flow response during neuronal activation was studied with functional magnetic resonance imaging (fMRI). Using a breath‐holding challenge as a hypercapnic stimulus, rCBF alterations during photic stimulation under normo‐ and hypercapnia were determined in nine volunteers. With breath‐holding, baseline rCBF in areas corresponding to the visual cortex significantly increased from 54 ± 5 ml/100 g/min to 85 ± 9 ml/100 g/min ( P < 0.001). Despite this significant change in baseline flow values, the rCBF increase during visual stimulation was very similar under normo‐ and hypercapnic conditions (28 ± 8 ml/100 g/min versus 26 ± 8 ml/100 g/min, respectively). This study supports the notion that within wide physiologic variations, task‐induced cerebral blood flow changes are independent of baseline rCBF values. J. Magn. Reson. Imaging 2000;12:757–762. © 2000 Wiley‐Liss, Inc.