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Acquired generalized lipoatrophy (AGL): Highly selective MR lipid imaging and localized 1 H‐MRS
Author(s) -
Brechtel Klaus,
Jacob Stephan,
Machann Juergen,
Hauer Bastian,
Nielsen Mette,
Meissner Hans P.,
Matthaei Stephan,
Haering Hans U.,
Claussen Claus D.,
Schick Fritz
Publication year - 2000
Publication title -
journal of magnetic resonance imaging
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.563
H-Index - 160
eISSN - 1522-2586
pISSN - 1053-1807
DOI - 10.1002/1522-2586(200008)12:2<306::aid-jmri13>3.0.co;2-w
Subject(s) - adipose tissue , steatosis , abdomen , medicine , magnetic resonance imaging , lipid metabolism , endocrinology , pathology , anatomy , radiology
Frequency‐selective chemical shift magnetic resonance (MR) imaging was applied on the calf musculature and the abdomen of a patient with acquired generalized lipoatrophy (AGL; Lawrence syndrome), a very rare syndrome affecting selectively several types of adipose tissue accompanied by alterations in glucose and energy metabolism. In addition, 1 H‐MRS was used for assessment of intra‐ (IMCL) and extramyocellular lipid stores (EMCL) in the skeletal musculature of the calf. Results from the AGL patient were compared with an age‐matched group of five healthy volunteers. Fat‐selective imaging of the calf revealed a total lack of subcutaneous adipose tissue. No EMCL signal was found in the spectra from the soleus muscle of the AGL patient. IMCL signals were present in the spectra but were clearly lower than in the controls (14% of normal value in the soleus muscle). In abdominal images, subcutaneous fat signal was not detectable, as in the calf, but nearly normal conditions were shown for visceral adipose tissue between abdominal organs. Fat‐selective images showed the liver with high signal intensity, indicating hepatic steatosis combined with hepatosplenomegaly. Modern chemical shift‐selective MR imaging and localized spectroscopy allow a noninvasive and quantitative assessment of tissue composition in patients with disorders of carbohydrate and lipid metabolism. J. Magn. Reson. Imaging 2000;12:306–310. © 2000 Wiley‐Liss, Inc.